Click Reagents

The classic “click” reaction based on the Staudinger ligation utilizes two reaction ends—an azide and an alkyne—with a Cu(I) reagent that “clicks” the components together into an extremely stable 1,2,3-triazole linkage. The ability to modify separate linker ends, the absence of alkynes and azides in biological systems, and a lack of steric interference on native biological activity, makes these PEG reagents a popular choice for bioorthogonal click reactions.